This is the 160th Subnormality comic.
PHG is approached by a stranger who asks her to watch his dog. She is reluctant, but becomes distracted when she realises that the "dog" is in fact a safe. The man explains that the dog is in the safe, due to a long and dubious backstory involving a pet store robbery. Although the man is clearly unreliable, PHG feels obliged to do as he asks, and winds up watching the safe until after nightfall, while a meowing sound issues from within.
There is then a short illustration of a board game for PHG's life: on the path back to her apartment, every square has an encounter which either causes one to miss a turn or costs money.